Fig. 3: Genetic correlation analyses.
The genome-wide genetic correlation of POP GWAS meta-analysis summary statistics with 561 phenotypes was estimated using LDSC regression. Data is presented as means +− SEM. We accounted for multiple testing using a Bonferroni correction for 561 tests (0.05/561 = 8.91 × 10−5) and derived genetic correlation estimates (showed as circles). Phenotypes summary statistics come from published GWASs (n = 43 phenotypes) and GWASs of UK Biobank data (n = 518 phenotypes), available in LD-Hub v1.9.3. Significant genetic correlations showcased in the plot reveal overlap of genetic risk factors for POP across several groups of traits (grouped by colors): anthropometric (red dots; including body fat percentage (n = 354,628), body mass index (n = 354,831), waist circumference (n = 360,564), waist-to-hip ratio (n = 224,459), cardiometabolic (yellow dots; including blood clot in the leg (DVT) (n = 7,386 cases and 353,141 controls), angina (n = 11,372 cases and 349,048 controls), diabetes diagnosed by doctor (n = 17,275 cases and 342,917 controls), triglycerides (mmol/L) (n = 343,992), coronary artery disease (n = 60,801 cases and 123,504 controls)), ICD10 diagnoses (green dots; including R10 Abdominal and pelvic pain (n = 20,240 cases and 340,954 controls), N92 Excessive frequent and irregular menstruation (n = 8,475 cases and 185,699 controls), K57 Diverticular disease of intestine (n = 12,662 cases and 348,532 controls), job type (light blue dots; including Job involves heavy manual or physical work (n = 205,000), Job involves mainly walking or standing, n = 204,956), reproductive traits (dark blue dots; including Ever had hysterectomy (n = 13,973 cases and 157,440 controls), Age at first live birth (n = 131,987), Number of liver births (n = 193,953)) and self-reported conditions (pink dots; including Hiatus hernia (n = 32,590), Osteoarthritis (n = 30,046 cases and 331,095 controls), Gastro-esophageal reflux (n = 15,210 cases and 345,931 controls), Heart attack/myocardial infarction (n = 8,239 cases and 352,902 controls)). Study source can be found in Supplementary Data 8. Center values show the estimated genetic correlation (rg), which is presented as a dot and error bars indicate 95% confidence limits. Dotted black line indicates no genetic correlation. ICD International Classifications of Diseases 10th Revision, DVT Deep Venous Thrombosis.
