Fig. 5: Predictive ability of PRS and clinical variables in incident status. | Nature Communications

Fig. 5: Predictive ability of PRS and clinical variables in incident status.

From: Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse

Fig. 5

Green dots represent polygenic risk score (PRS), orange dots represent five established risk factors and purple dots represent genetic and/or clinical combined models C-statistic (C-stat) indexes. Data are presented as means +/− SEM in both panels. Cox proportional hazard models were used and age was used as a time scale for properly accounting for left-truncation and right-censoring in the data in both models. a C-stat for clinical variables and PRS alone or in combination in the validation subset of Estonian Biobank (2104 cases and 24,753 controls). b C-stat adjusted by batch effects and 10 first principal components in the validation subset of Estonian Biobank (2104 cases and 24,753 controls).

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