Fig. 2: Inducible gene transcription is driven primarily by the fraction of expressing cells.
From: Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters
Left: heatmap of transcript levels (CPM) of inducible macrophage primary and secondary response genes30 detected by scRNA-seq in at least 20% of cells. Centre: Fraction of cells with detectable transcripts for each of six previously defined classes of inducible genes30 at 0, 2 and 8 h after LPS activation. Right: Transcript levels (CPM+1) per transcript-positive cell is shown for the same classes of inducible genes at 0, 2 and 8 h after LPS activation. Numbers represent adjusted P values for 0 versus 2 h and 0 versus 8 h. Two-sided Wilcoxon signed-rank test with Bonferroni correction for multiple testing. N = 682 cells.
