Fig. 5: SARS-CoV-2 NP viral antigen is still detectable after 4 dpi in the trachea of VOC Omicron infected hamsters. | Nature Communications

Fig. 5: SARS-CoV-2 NP viral antigen is still detectable after 4 dpi in the trachea of VOC Omicron infected hamsters.

From: SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

Fig. 5

A Representative images showing SARS-CoV-2 nucleoprotein (NP) immunolabeling in the trachea of hamsters infected with VOCs Gamma, Delta, Omicron or 614 G strain. Viral antigen (brown signal) was only detected in the tracheal epithelium of hamsters infected with VOC Omicron. Scale bars = 50 µm. B Quantification of SARS-CoV-2 NP antigen revealed a significantly higher number of immunolabeled cells in the trachea of hamsters infected with VOC Omicron compared to hamsters infected with VOCs Gamma, Delta or the 614 G strain. Data are shown as box and whisker plots. The bounds of the box plot indicate the 25th and 75th percentiles, the bar indicates medians, and the whiskers indicate minima and maxima. Data were tested by two-tailed Mann–Whitney-U tests followed by Benjamini–Hochberg correction. A p-value of ≤0.05 was chosen as the cut-off for statistical significance. N = 5 animals/group for VOCs Gamma and Delta and 6 animals/group for VOC Omicron and 614 G. For quantifications, one entire cross- and one entire longitudinal section were evaluated per animal. Source data are provided as a Source Data file.

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