Fig. 2: Mitotic cycle duration covaries with nuclear density, explaining a marked decline in division synchronicity. | Nature Communications

Fig. 2: Mitotic cycle duration covaries with nuclear density, explaining a marked decline in division synchronicity.

From: Nuclear speed and cycle length co-vary with local density during syncytial blastoderm formation in a cricket

Fig. 2

a Percent change in the total number of observable nuclei over time. Divisions become increasingly asynchronous over the course of syncytial development. b Example lineage of dividing nuclei, starting with one of the nuclei at the four nucleus stage with divisions marked in turquoise. Over four division cycles, mean cycle duration increased from 49 to 87 minutes. ce Cell cycle duration was positively associated with local density. Cell cycle duration was calculated in the vicinity of each nucleus by measuring the time elapsed until the number of nuclei within a 150 µm radius increased by 25%. Top row shows three example time points, with local cell cycle duration displayed as colored volumes, each of which contains a single nucleus. Bottom row shows scatterplots of the local cell cycle duration times and nuclear densities at each time point; n = number of nuclei. Source data are provided as a Source Data file.

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