Fig. 5: SD-CNN saliency scores highlight known and plausible new resistance-conferring loci. | Nature Communications

Fig. 5: SD-CNN saliency scores highlight known and plausible new resistance-conferring loci.

From: A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis

Fig. 5

Variants not known to cause resistance according to the WHO27 are shown in purple. a Maximum of absolute value DeepLIFT saliency scores for the isoniazid SD-CNN across all isoniazid-resistant loci. b High-importance variants in the InhA protein mapped to its crystal structure72. c High-importance variants in the PncA protein mapped to its crystal structure73. d Maxima of absolute value DeepLIFT saliency scores for the pyrazinamide SD-CNN in the pncA locus.

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