Fig. 3: ZCB11 resistance to natural mutations in SARS-CoV-2 VOCs and comparison with four public antibodies derived from IGHV1-58 family.
From: A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
a Fold change of IC50 values relative to WT was determined by pseudoviruses carrying individual mutations or deletion against ZCB3 and ZCB11 as compared with ZB8. b Binding kinetics of ZCB11 to SARS-CoV-2 RBD was determined by SPR as compared with four public antibodies derived from IGHV1-58 family. The color coding indicates each individual antibody. c Neutralization of pseudotyped Omicron BA.1 by ZCB11 and four public antibodies as compared with two therapeutic antibodies (S309 and LY-CoV1404). The experiments were performed in duplicates. Source data are provided as a Source Data file. VOC variant of concern, IC50 half inhibitory concentration, WT wildtype, RBD receptor-binding domain, SPR surface plasmon resonance.
