Fig. 3: Age dependency of the mutation profile.
From: Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age
A Comparison of mutation counts between age groups, using the usual age cutoff of 18 years for adult patients. Mutations in ID3, DDX3X, SMARCA4, GNA13, ARID1A, and PTEN are significantly more frequent in pediatric patient samples, while BCL2, YY1AP1, PIM1, CREBBP, CARD11, SOCS1, and DTX1 are significantly more frequently altered in the adult cohort (P values by one-sided exact Fisher tests, see Supplementary Data 8 for exact P values and FDRs, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001). B A cutoff-free enrichment analysis of mutation densities over age largely confirms cutoff-based results but reveals that the main biological transition of the mutational profile occurs later between 25 and 40 years (P values by one-sided enrichment analysis and permutation test with 1e5 permutations per tail).
