Fig. 6: Mutational overview of TP53, PCBP1, FBXO11, and FOXO1 at the amino acid level in the adult (top) and pediatric (bottom) cohort.
From: Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age
A TP53 shows an accumulation of known hotspots at R175, R248, R273, R282, and G245 as found in other malignancies. B PCBP1 shows a hotspot truncation mutant (Y183*) identified in both age groups. C FBXO11 alterations are unique except for W112*. Most mutations were found in the β-helix domain. D In total, 74% of all pediatric FOXO1 mutations span the Akt phosphorylation motif on R19, R21, and T24. Exon boundaries are indicated using dashed lines.
