Fig. 3: Custodial variability of MiaPaca2 cell lines drives transcriptomic heterogeneity.
From: Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution
a UMAP overlaying MP2 samples and their distinct clusters. b Bar graph displaying distribution of cells per MP2 culture across clusters; MP2-A in red, MP2-B in green and MP2-C in blue. c Bubble plot showing enrichment of pathways in MP2 cultures compared to each other with normalized enrichment score (NES) on the x-axis. Size of the bubble represents false discovery rate (FDR); red indicates upregulation, blue indicates downregulation of the pathway. d inferCNV heatmaps derived from scRNAseq data of all three MP2 samples, using HPNE as an analytical reference.
