Fig. 4: Evolution of divergent genomic subclones in MiaPaca2 strains has transcriptomic implications.
From: Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution
a Genomic clones 1 (orange) and 2 (blue) identified from scCNV data of MP2-B based on CNV events at chromosomes 7, 10, and 12. b Percentage of cells assigned to clones from scCNV and scRNA datasets. scCNV clones were mapped to corresponding scRNA data using CloneAlign. c UMAP data of MP2-B scRNA expression of single cells overlaid with CNV clones assignment for each cell; Clone 1 in green and Clone 2 in pink. d–f Same as a–c for MP2-C.
