Fig. 4: Among significantly differentially abundant VCs some are related.
From: Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome
a VCs identified by ANCOM-BC as significantly abundant (q ≤ 0.05 after implementing the Benjamini–Hochberg procedure for multiple testing). Points show the log fold change as given by ANCOM-BC, error bars denote the standard error adjusted by the Benjamini–Hochberg procedure for multiple testing. The analysis was adjusted for smoking, age, sex, alcohol use, and metformin use. Red arrows mark related VCs further depicted in b. Taxonomic names to the right of the plot denote host predictions, which are colored as follows: Firmicutes; gray, Bacteroidetes; red, Actinobacteria; green, Proteobacteria; pink. The full taxonomies are listed in Supplementary Data 1 and 3. n = 97/n = 99 biologically independent samples for MetS and controls, respectively. b Whole-genome analysis of four contigs that belong to the VCs marked by red arrows in a. The top and bottom contigs are zoomed in on the prophage region. The read coverage depth of these contigs in samples where they are present/absent is depicted in the graphs at the top and bottom. The nine genes shared by all Candidatus Heliusviridae are colored red, and numbered as follows: 1: DUF2800-containing, 2: DUF2815-containing, 3: DNA polymerase I, 4: nuclease (VRR-NUC-containing), 5: SNF2-like helicase, 6: terminase large subunit, 7: portal protein, 8: Clp-protease, 9: major capsid protein. Source data are provided as a Source Data file.
