Fig. 1: Dynamics of the chromatin accessibility landscape during human and rhesus PFC development. | Nature Communications

Fig. 1: Dynamics of the chromatin accessibility landscape during human and rhesus PFC development.

From: Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human

Fig. 1

a Schematic of developmental stages examined in rhesus monkeys and humans. b The number of conserved and divergent regulatory elements between rhesus and human PFCs. c The dynamics of gene expression and the DHS signal of paired regulatory elements in rhesus (left) and human (right) PFC. The potential regulatory element-gene pairs are classified into 6 clusters by the K-means method. The middle panel shows the significantly enriched GO terms. Reg. represents regulation. In cluster 6, all the DHSs assigned to the orthologous genes, in addition to the DHSs detected separating the gene activation at different stages, are shown. d Genome browser view of the expression of PAX6 and the DHS signal of the paired regulatory elements during PFC development in rhesus monkeys (left) and humans (right). The light blue shadows mark the paired regulatory elements.

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