Fig. 2: The conservation and divergence of regulating models for orthologous genes. | Nature Communications

Fig. 2: The conservation and divergence of regulating models for orthologous genes.

From: Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human

Fig. 2

a Schematics showing three groups of regulatory element-gene pairs between humans and rhesus monkeys. E–C: Element sharing a conserved sequence between human and rhesus, E-HS: element with a human-specific sequence, E-RS: element with a rhesus-specific sequence. b Bar plots show the number of orthologous genes with conserved or divergent elements. c Heatmaps show the orthologous genes with conserved regulatory elements between rhesus monkeys and humans. Each row represents a conserved regulatory element-gene pair. d Genome browser view of expression of the NEUROG2 and the DHS signal of paired regulatory elements in rhesus and human PFC. The light blue shadows mark the paired regulatory elements. The paired regulatory elements of NEUROG2 gene have conserved sequences and chromatin states between humans and rhesus monkeys. The pink arrow indicates the potential regulatory effect of the regulatory element on NEUROG2. e Genome browser track shows that TRADD is not expressed in the human PFC (left) but is species-specific expressed in the rhesus PFC (right). The light blue shadow marks the position of potential regulatory element of this gene in rhesus monkeys. The sequence of this element is rhesus-specific and cannot be found in humans.

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