Fig. 4: Identification of human newly emerged regulatory elements. | Nature Communications

Fig. 4: Identification of human newly emerged regulatory elements.

From: Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human

Fig. 4

a The evolutionary tree of primates. b Box and jitter plots comparing SNP frequencies (SNP numbers per kb) between newly emerged DHSs (n = 3831) and conserved DHSs (n = 212,304) in the human population. Boxes and whiskers represent the 25th/75th percentiles and 1.5 \(\times\) the interquartile range, respectively. The center in the boxplot represents the medium value. Student’s t test with a two-sided model was used. c Genome browser view showing promoter DHS and expression of USP9X and VAMP2 during human PFC development. The pink shadow marks the newly emerged DHSs. d Enriched transcription factor binding motifs in newly emerged human DHSs. P values are calculated based on the hypergeometric distribution.

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