Fig. 6: The relationship between human cognitive performance and chromatin accessibility during PFC development. | Nature Communications

Fig. 6: The relationship between human cognitive performance and chromatin accessibility during PFC development.

From: Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human

Fig. 6

a Enrichment of educational attainment associated SNPs (n = 2191) in DHS regions in human PFCs exhibits a decreasing trend during development. Gray shading indicates 95% confidence intervals. b Enrichment of cognitive performance associated SNPs (n = 323) in DHS regions in human PFCs exhibits a decreasing trend during development. Gray shading indicates 95% confidence intervals. c GO analyses for educational attainment and cognitive performance SNP associated genes. P values are calculated based on the accumulative hypergeometric distribution and q-values are the multiple test adjusted p values and multiple testing is performed with the Banjamini-Hochberg method. d Genome browser view of the DHS signal near SH2B1 and RNA expression of SH2B1. Pink shadows mark the locations of SNPs which are associated with educational attainment and cognitive performance.

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