Fig. 1: Structures of RML, aRML, and 263 K prions from cryo-EM.

Core sequences of PrP subunits in a RML filaments and b aRML filaments. c Comparison of PrP conformations in RML and the 263 K prion fibrils. d Lateral views of aRML and 263 K fibrils showing stacks of three rungs. a and c are adapted from Manka et al.; b and d are adapted from Hoyt et al.