Fig. 3: Bivariate genetic correlation estimates between pneumonia susceptibility and psychiatric phenotypes. | Nature Communications

Fig. 3: Bivariate genetic correlation estimates between pneumonia susceptibility and psychiatric phenotypes.

From: The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness

Fig. 3

Genetic correlation was estimated between ten psychiatric GWAS and pneumonia susceptibility GWAS. The forest plot denotes the linkage disequilibrium genetic correlation estimate, whilst the error bars are the 95% confidence internal. The different pneumonia GWAS effect sizes utilised with the panel of psychiatric disorders was as follows: top left – genome-wide meta-analysis of self-reported and clinically ascertained pneumonia; top right – genome-wide meta-analysis of self-reported and clinically ascertained pneumonia genetically conditioned on smoking heaviness (cigarettes per day); bottom left – clinically ascertained pneumonia from FinnGen, and bottom right – self-reported pneumonia from 23andMe. The psychiatric phenotypes were as follows: TS = Tourette’s syndrome (N = 14,307), SZ = schizophrenia (130,644), PTSD = post-traumatic stress disorder (N = 174659), OCD = obsessive compulsive disorder (N = 9725), cognition = general cognitive ability (intelligence, N = 269,867), BIP = bipolar disorder (N = 51,890), ASD = autism spectrum disorder (N = 36,350), AN = anorexia nervosa (N = 72,517), and ADHD = attention/deficit-hyperactivity disorder (N = 53,293).

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