Fig. 1: Humoral immunogenicity outcomes for adolescents were mostly non-inferior in adolescents in comparison to adults. | Nature Communications

Fig. 1: Humoral immunogenicity outcomes for adolescents were mostly non-inferior in adolescents in comparison to adults.

From: Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents

Fig. 1

a One dose of BNT162b2 (B) in adolescents was non-inferior by S-RBD IgG (adolescent B N = 107, adult BB N = 115), sVNT (adolescent B N = 107, adult BB N = 115) and S IgG avidity (adolescent B N = 88, adult BB N = 114) but not by S IgG (adolescent B N = 101, adult BB N = 115), PRNT90 (adolescent B N = 63, adult BB N = 13), PRNT50 (adolescent B N = 63, adult BB N = 13) and S IgG FcγRIIIa-binding (adolescent B N = 101, adult BB N = 115) (all P < 0.0001, except S IgG avidity with P = 0.13), which failed the non-inferiority comparison to adults. Additionally, although non-inferiority was satisfied for S-RBD IgG and sVNT for B in adolescents, their CIs were also within the inferior ranges (both P < 0.0001). b In contrast, humoral responses in adolescents were non-inferior to adults after 2 doses of BNT162b2 (BB), as measured by S IgG (also superior, P = 0.0036, adolescent BB N = 103), S-RBD IgG (P = 0.23, adolescent BB N = 103), sVNT (also superior, P < 0.0001, adolescent BB N = 104), PRNT90 (also superior, P = 0.018, adolescent BB N = 60), PRNT50 (P = 0.25, adolescent BB N = 60), S IgG avidity (also superior, P < 0.0001, adolescent BB N = 103) and S IgG FcγRIIIa-binding (also superior, P = 0.0005, adolescent BB N = 103). c After 2 doses of CoronaVac (CC), adolescents also had non-inferior humoral responses to adults as assessed by S IgG (also superior, P = 0.0049, adolescent CC N = 116, adult CC N = 50), S-RBD IgG (P = 0.96, adolescent CC N = 119, adult CC N = 51), sVNT (also superior, P < 0.0001, adolescent CC N = 119, adult CC N = 51), PRNT90 (P = 0.08, adolescent CC N = 64, adult CC N = 19), PRNT50 (P = 0.12, adolescent CC N = 64, adult CC N = 19), S IgG avidity (also superior, P < 0.0001, adolescent CC N = 109, adult CC N = 41) and S IgG FcγRIIIa-binding (P = 0.086, adolescent CC N = 116, adult CC N = 50). Additionally for adolescent CC, N and N-CTD IgGs were non-inferior and superior for adolescents compared to adults (both P < 0.0001, adolescent CC N = 60, adult CC N = 36). GMR geometric mean ratio, CI confidence interval, S spike protein, RBD receptor-binding domain, N nucleocapsid protein, CTD C-terminal domain, sVNT surrogate virus neutralisation test, PRNT plaque reduction neutralisation test, FcγRIIIa Fcγ receptor IIIa.

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