Fig. 1: Cryo-EM maps of Xenopus KCNQ1-CaM alone and in complex with ML277.
From: Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277
a Cryo-EM density map of Xenopus KCNQ1-CaM (xKCNQ1-CaM), and its model structure (c). CaM is colored dark green and KCNQ1 subunits are in shades of red. b xKCNQ1-CaM in complex with ML277 and its model structure (d). CaM and ML277 are colored dark green and orange, respectively. KCNQ1 subunits are in shades of blue. Additional densities, likely representing unmodeled detergent or lipid molecules are shown in gray. For further analysis of these densities, see Supplementary Fig. 7. e Overall superposition of a single subunit of xKCNQ1-CaM and xKCNQ1-CaM-ML277 shows a visible twist in the C-helix coiled-coil domain (CTD). HA-HC refers to helices within the C-terminal domain of KCNQ1.
