Fig. 2: THZ1 blocks stress-responsive gene programs and Pol II enrichment in cultured cardiomyocytes.
From: Targeting transcription in heart failure via CDK7/12/13 inhibition
A Schema of the experimental design. ChIP-seq for total Pol II was performed for 3 conditions: baseline, PE, and PE + THZ1. B A heatmap showing clustered, row-normalized global gene expression profile in each sample in the indicated treatment group (n = 3) with representative gene callouts. C Representative gene tracks of Pol II enrichment for canonical hypertrophic marker genes (Nppb and Nppa). D Accumulative Pol II occupancy on all promoters. E Empirical cumulative distribution plots of Pol II traveling ratios (TR) for genes that are differentially expressed in response to PE stimulation (PE vs baseline). TR is defined as the ratio of (Pol II signal at TSS) / (Pol II signal at gene body). ****p < 0.0001 for indicated comparisons. Source data are provided as a Source Data file.
