Fig. 3: Cardiac loss of SDHAF4 provokes dilated cardiomyopathy.
a Postnatal bodyweight curves of WT (Sdhaf4fl/fl, n = 6) and Sdhaf4 mutant mice (Sdhaf4fl/fl, Ckmm-Cre, n = 6). b Postnatal heart weight curves of WT (n = 6) and Sdhaf4 mutant mice (n = 6), P = 0.002, 0.0001, 0.0018, 0.0001. c Macroscopic pictures and H/E histology of hearts of WT and mutant mice, scale bar, 1 cm. d Representative cardiac Masson trichrome staining of WT and mutant mice at age of 4 and 7 weeks, and Sirius red staining of WT and mutant mice at age of 7 weeks, scale bar, 3 mm. e Relative expressions of hypertrophic and fibrotic-associated genes in left ventricle of WT and muscle Sdhaf4 mutant mice, n = 6, P < 0.0001. f Relative expressions of hypertrophic and fibrotic-associated genes in left ventricle of WT and cardiac Sdhaf4 mutant mice, n = 6, P < 0.0001. Values are mean ± SEM, *P < 0.05, **P < 0.01. Statistical significance was determined by two-tailed Student’s t-test (b, e, f). Source data are provided in Source Data file.
