Fig. 8: Fumarate supplement improves cardiac function in MI mice. | Nature Communications

Fig. 8: Fumarate supplement improves cardiac function in MI mice.

From: Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy

Fig. 8

a Heart weight / bodyweight ratio of control and MI mice with or without fumarate supplement for 7 days, n = 7, P < 0.0001. b–f Heart function measurements of control and MI mice with or without fumarate supplement for 3 and 7 days (n = 6 for Sham and Sham + Fumarate groups, n = 8 for MI and MI + Fumarate groups): corrected LV mess (b, P < 0.0001), EF (c, P < 0.0001), FS (d, P < 0.0001), LVEDV (e, P < 0.0001), and LVESV (f, P < 0.0001). g Relative expressions of hypertrophic and fibrotic-associated genes in left ventricle of control and MI mice with or without fumarate supplement, n = 6, P < 0.0001. Values are mean ± SEM, **P < 0.01. Statistical significance was determined by two-tailed Student’s t-test (a–g). Source data are provided in Source Data file.

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