Fig. 4: Pattern decorrelation enables social preference in WT mice but is impaired in Rett mice. | Nature Communications

Fig. 4: Pattern decorrelation enables social preference in WT mice but is impaired in Rett mice.

From: Pattern decorrelation in the mouse medial prefrontal cortex enables social preference and requires MeCP2

Fig. 4

a Raster plots of calcium activity of individual mPFC neurons during interactions with different stimuli, from representative WT and Rett mice. Calcium transient traces are sorted by the peak activity time of social interaction (left top) and object interaction (right bottom), while the calcium traces of those sorted neurons in responding to object (top right) and social (bottom left) stimuli were also plotted in the same sequence of the sorted plot. b Distribution of pair-wise Pearson correlation coefficients among all recorded mPFC neurons of WT (Mecp2+/+; n = 9) and Rett (Mecp2+/−; n = 8) mice in responding to stimuli in each session. The black and red plots represent M1 interactions, while the lighter colors (grey and pink) represent the interaction with the other stimulus (O or M2). c The averaged full width at half maximum (FWHM) of correlation coefficient distribution (b) of individual WT mice (n = 9) and Rett mice (n = 8) during interactions with different stimuli. Data are represented as mean ± SEM. *P < 0.05, **P < 0.01, two-way RM ANOVA with Bonferroni–corrected post hoc comparisons. d The relationship between ΔFWHM and the discrimination index in each mouse, by genotype. In Rett, the ΔFWHM is centered around zero, meaning little or no decorrelation; the discrimination index is mostly below zero. n = 9 WT and 8 Rett mice. Each dot represents an individual mouse; Pearson’s correlation coefficients were calculated across genotypes. **P < 0.01, ***P < 0.001, regression.

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