Fig. 2: Pathways activated in children and adults upon SARS-CoV-2 infection.
From: Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children
a Normalized enrichment scores of selected GO biological process terms that reached statistical significance (adjusted p-value < 0.05) in the gene set enrichment analysis (GSEA) using differentially expressed (DE) genes between the SARS-CoV-2 and No Virus groups in either the adult or pediatric cohort. Color indicates the age cohort. Pathway p-values were calculated using an adaptive, multilevel splitting Monte Carlo approach and Benjamini–Hochberg adjusted, and statistical significance is denoted by a black outline around the circle. Complete results are provided in Supplementary Data 3. b Normalized enrichment scores for the same GO terms as in (a) in the GSEA using DE genes between children and adults with SARS-CoV-2 infection. Dark color bars represent pathways that reached statistical significance (adjusted p-value < 0.05). Complete results are provided in Supplementary Data 5.
