Table 1 Adult and Pediatric cohort characteristics.
From: Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children
Adult Cohort | Pediatric Cohort | Adult vs Pediatric | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cohort Overall | SARS-CoV-2 | Other Virus | No Virus | p-value | Cohort Overall | SARS-CoV-2 | Other Virus | No Virus | p-value | Overall p-value | SARS-CoV-2 p-value | |
Total Enrolled (n) | 154 | 45 | 28 | 81 | 83 | 38 | 11 | 34 | ||||
Age, years (median, range, IQR) | 62 (40–89, 47–71) | 57 (40–82, 44–64) | 61.5 (40–89, 45–73) | 62 (41–89, 52–72) | 0.07 | 4 (<1–19, 2–12) | 5 (<1–19, 2–11) | 3 (<1–14, 2–11) | 4 (<1–16, 2–12) | 0.97 | ||
Female gender | 78 (51%) | 25 (56%) | 10 (36%) | 43 (53%) | 0.21 | 42 (51%) | 16 (42%) | 7 (64%) | 19 (56%) | 0.38 | 0.93 | 0.27 |
Clinical Encounter Type | ||||||||||||
Inpatient | 42 (27%) | 4 (9%) | 9 (32%) | 29 (36%) | 31 (37%) | 1 (3%) | 2 (18%) | 28 (82%) | ||||
Intensive Care Unit | 16 (10%) | 2 (4%) | 5 (18%) | 9 (11%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | ||||
Emergency Department | 24 (16%) | 3 (7%) | 6 (21%) | 15 (19%) | 19 (23%) | 6 (16%) | 8 (73%) | 5 (15%) | ||||
Outpatient | 55 (36%) | 24 (53%) | 8 (29%) | 23 (28%) | 31 (37%) | 30 (79%) | 0 (0%) | 1 (3%) | ||||
Unknown | 17 (11%) | 12 (27%) | 0 (0%) | 5 (6%) | 0.003 | 2 (2%) | 1 (3%) | 1 (9%) | 0 (0%) | <0.001 | 0.59 | 0.23 |
Race | ||||||||||||
White or Caucasian | 67 (44%) | 6 (13%) | 19 (68%) | 42 (52%) | 34 (41%) | 13 (34%) | 4 (36%) | 17 (50%) | ||||
Asian | 25 (16%) | 6 (13%) | 5 (18%) | 14 (17%) | 6 (7%) | 1 (3%) | 1 (9%) | 4 (12%) | ||||
Black or African American | 14 (9%) | 1 (2%) | 1 (4%) | 12 (15%) | 4 (5%) | 2 (5%) | 2 (18%) | 0 (0%) | ||||
Native Hawaiian or Pacific Islander | 1 (1%) | 1 (2%) | 0 (0%) | 0 (0%) | 2 (2%) | 0 (0%) | 1 (9%) | 1 (3%) | ||||
American Indian or Alaska Native | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (1%) | 0 (0%) | 0 (0%) | 1 (3%) | ||||
Other | 27 (18%) | 17 (38%) | 3 (11%) | 7 (9%) | 29 (35%) | 17 (45%) | 2 (18%) | 10 (29%) | ||||
Unknown | 20 (13%) | 14 (31%) | 0 (0%) | 6 (7%) | <0.001 | 7 (8%) | 5 (13%) | 1 (9%) | 1 (3%) | 0.31 | 0.013 | 0.1 |
Ethnicity | ||||||||||||
Not Hispanic or Latino | 109 (71%) | 16 (36%) | 26 (93%) | 67 (83%) | 43 (52%) | 10 (26%) | 7 (64%) | 26 (76%) | ||||
Hispanic or Latino | 23 (15%) | 14 (31%) | 1 (4%) | 8 (10%) | 34 (41%) | 23 (61%) | 3 (27%) | 8 (24%) | ||||
Unknown | 22 (14%) | 15 (33%) | 1 (4%) | 6 (7%) | <0.001 | 6 (7%) | 5 (7%) | 1 (9%) | 0 (0%) | <0.001 | <0.001 | 0.06 |
