Fig. 4: NK cell eQTL determine protein expression on NK cells in patients with metastatic melanoma. | Nature Communications

Fig. 4: NK cell eQTL determine protein expression on NK cells in patients with metastatic melanoma.

From: Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity

Fig. 4

Genotype-phenotype correlations are calculated by linear regression. P values are calculated with likelihood ratio tests. Expression of CD57 (orange, n = 78) and CD226/DNAM1 (blue, n = 24) protein on NK cells is determined by the respective RNA eSNPs in patients with metastatic melanoma. KIR2D antigen expression on NK cells in patients with metastatic melanoma (n = 78) is modified by KIR2DS4del copy number (pink). Box and whisker plots; boxes depict the upper and lower quartiles of the data, and whiskers depict the range of the data excluding outliers (outliers are defined as data-points > 1.5 × the inter-quartile range from the upper or lower quartiles). Genotype to phenotype correlations were calculated with linear regression. P values are two-sided.

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