Fig. 5: Exploring the effect of unnatural oligosaccharides on the assembly of R5.

a Chemical structure of N-acetyl glucosamine hexasaccharide N₆ and sulfated hexasaccharide (SA)₃. b AFM (Day 1 and Day 5), TEM (Day 5) images, and CD spectra of fibrils prepared with R5 in the presence of N₆ or (SA)₃.