Fig. 3: Inhibitory role of AnxA1 in inflammatory osteolysis induced by implant debris. | Nature Communications

Fig. 3: Inhibitory role of AnxA1 in inflammatory osteolysis induced by implant debris.

From: Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis

Fig. 3

a Quantification of the lytic area in calvarial bone tissues of wild-type WT and AnxA1-deficient mice after implantation of UHMWPE as analyzed by micro-CT. Results represent the mean ± SEM of 6 mice. b, c Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone sections. Results represent the mean ± SEM of 6 mice. d Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm. e Quantification of the lytic area in calvarial bone tissues of mice that received a function-blocking antibody (AnxA1. Ab) or a control (Con. Ab) analyzed by micro-CT. f, g Quantification of TRAP-stained areas and inflammatory infiltrate in calvarial bone sections of Ab-treated mice. Results represent the mean ± SEM of 6 mice. h Representative images for micro-CT and histological observations of bone sections stained by TRAP and H&E. Scale bar 100 µm Significant difference between the two groups was determined by two-tailed Student’s t test. *p < 0.05, **p < 0.001. ns indicates no significant difference. Source data are provided as a Source Data file.

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