Fig. 2: Targeted analysis of the lysine metabolism reveals renal alterations in hypertension and degradation via the Nα-saccharopine pathway. | Nature Communications

Fig. 2: Targeted analysis of the lysine metabolism reveals renal alterations in hypertension and degradation via the Nα-saccharopine pathway.

From: Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

Fig. 2

A Chemical pathways for lysine Nα- and Nε-degradation. B Experimental design to analyze lysine fate in Dahl salt-sensitive rats. C Overview of lysine metabolite isotope signal in D. Corrected ratios of 15N/14N labeled compounds in different organs (n = 3 rats/group). E Proximal mouse tubules were incubated with 15Nε lysine ex vivo (n = 3 independent experiments performed in time course), error bar = SD. Source data for this figure is available.

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