Fig. 3: Counteracting lysine deficiency in hypertension ameliorates the disease by physiological mechanisms. | Nature Communications

Fig. 3: Counteracting lysine deficiency in hypertension ameliorates the disease by physiological mechanisms.

From: Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

Fig. 3

A Lysine administration protocol for rats. B Mean arterial pressure (MAP) in male D/SS rats under L-lysine treatment (n ≥ 7 animals per group), error bar = SEM. C Albuminuria (normalized to creatinine) in control and L-lysine treated D/SS rats (n = 6 animals per group), error bar = SD. D 15N-lysine administration and lysine treatment protocol for rats. 15N isotope-labeled lysine treatment protocol to analyze lysine trace in presence of excess lysine. E Metabolomic analysis and signal distribution of 15N lysine-labeled metabolites in urine (n = 3 animals). F Lysine amplifies hypertension-induced diuresis (diuresis/24 h) (n = 7,8 animals), error bar = SEM. Source data for this figure is available.

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