Fig. 7: Lysine challenge does not develop protection or metabolic perturbation in spontaneous hypertensive rats (SHR), a hypertensive model without kidney disease.
From: Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension
A Proteinuria in SHR rats compared to DSS rats (n = 6 independent animals), error bars = SD. B Effect of Lysine supplementation on the mean arterial pressure (MAP) in SHR rats (n = 6 independent animals), error bars = SD. C Effect of lysine supplementation on the formation of Nε-acetyllysine. Kidney and liver Nε-acetyllysine increases in D/SS rats with comparable hypertension, but not in SHR rats (n ≥ 4 animals per group). D Effect of lysine supplementation on urinary TCA cycle metabolome (n ≥ 4 animals). Source data for this figure is available.
