Fig. 2: mRNA m6A modification regulates function acquiring across pancreatic specification.
a Nightingale rose diagram showing the percentage of m6A peaks inherited from the previous stage or de novo arose at current stage. b Stacked histogram showing the origin of m6A peaks at stages in pancreatic differentiation. c Bubble plots of KEGG pathways enriched in inherited and de novo established m6A peaks related genes in DE, PPs, and hILOs. Cycle size represents the gene numbers in each pathway, blue or green gradient represents the p-value of each pathway, p-values were calculated by one-tailed hypergeometric test. d Stacked histogram showing the percentage of genes with different numbers of m6A peaks in hPSCs, DE, PPs, and hILOs. e Heatmap of KEGG pathways enriched in genes with different numbers of m6A peaks in hPSCs, DE, PPs, and hILOs, p-values were calculated by one-tailed hypergeometric test. f Density scatter plot showing the correlation of gene expression and m6A level from hPSCs to DE, p-value was calculated by two-tailed hypothesis test. g Pie charts showing the specific correlation between mRNA levels and m6A abundance from hPSCs to hILOs.
