Fig. 3: Subgroup analysis of PFS.

Data are median for ITT population in clinically relevant subgroups. Subgroup included patients with <40 years (n = 45) and ≥40 years (n = 208); ECOG = 0 (n = 40) and ECOG = 1 (n = 213); premenopausal status (n = 113) and postmenopausal status (n = 140); de novo stage IV (n = 48), disease-free survival <1 year (n = 29) and ≥1 year (n = 176); No. of metastatic organ site = 1 (n = 94), =2 (n = 81) and ≥3 (n = 78); visceral metastasis (n = 163) and no visceral metastasis (n = 90); previous treatment with anthracycline (n = 173) and with no anthracycline (n = 80); previous treatment with taxane (n = 170) and with no taxane (n = 83). HRs and corresponding 95% CIs were estimated using Cox-proportional-hazard regression model. Data are presented as HR and 95% CI. HR hazard ratio, ECOG Eastern Cooperative Oncology Group.