Fig. 5: Immune-based subtyping of pan-SCCs. | Nature Communications

Fig. 5: Immune-based subtyping of pan-SCCs.

From: Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Fig. 5

a Coxcomb diagrams showing the distribution of 17 SCCs in 6 subtypes, including (1) Classical squamous (ClSq), (2) Fatty acid metabolic (FaSq), (3) Basophils inflamed (BaSq), (4) Neutrophils inflamed (NeSq), (5) Eosinophils inflamed (EoSq), and (6) Immune hot (IhSq). b Proteome-based microenvironmental cell signatures and over-represented pathways in 6 subtypes. c Represented morphologies of SCCs with specific tumor microenvironment cell infiltrating in 4 subtypes (subtype 1, 4–6). Arrows depict the specific cell types. Basophils were not shown because they cannot be recognized by HE staining. Scale bar, 100 μm. d Haematoxylin and eosin (H&E) stained and PLIN1 immunohistochemistry (IHC) images showing one example of subtype 2 samples with suspected lipid droplets. e Drug targets in 6 subtypes (drug targets discussed in the text were in bold).

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