Fig. 6: Characterization of HPV-related SCCs. | Nature Communications

Fig. 6: Characterization of HPV-related SCCs.

From: Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Fig. 6

a HPV infection rate of 5 anogenital SCCs. b Details of HPV infection and protein abundance of known molecules related to HPV infection of 5 anogenital SCCs. c Grouping of 5 anogenital SCCs according to HPV16 infection status and 5 groups were obtained. d Impact of HPV status on pathways in 5 anogenital SCCs. The heatmaps showed protein-expression derived, differentially regulated pathways associated with differential HPV infection. Pathway groups were defined according to the patterns of differential HPV infection. See also “Methods” and Table S6B. e Boxplots showing log2 protein abundance of differentially expressed molecules in two pathways that were over-represented in HPVT16 infected SCCs (Kruskal–Wallis test, BH-adjusted p < 0.05). n1 = 32, n2 = 16, n3 = 16, n4 = 11, and n5 = 19 biologically independent samples examined. Data are expressed as mean values ± SEM. The boxes indicate the interquartile ranges, and no outliers are shown. f Diagram depicted our hypothesis of inositol phosphate catabolic process upregulation and negative regulation of T cell receptor signaling contributing to HPV16-related SCC tumorigenesis. Source data are provided as a Source Data file.

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