Fig. 4: Relations between epilepsy gene expression and network topology.
Gene expression levels associated with (i) all other epilepsy subtypes (all epilepsy, focal epilepsy, juvenile myoclonic epilepsy, and childhood absence epilepsy), (ii) monogenic epilepsy, and (iii) anti-epileptic drug targets were mapped to cortical and subcortical surface templates. Spatial correlations were performed between each of these transcriptomic maps and the patterns of multivariate topological alterations in TLE and IGE across cortical and subcortical regions (n = 82) and were statistically assessed using one-tailed, non-parametric tests. In IGE, spatial associations between microarray data and multivariate topological changes were significant for expression levels of all epilepsy genes (r = 0.37, pspin = 0.0019) and focal epilepsy (r = 0.27, pspin = 0.015). In TLE, network associations did not correlate with any other epilepsy-related transcriptomic maps. HC = healthy control, IGE = idiopathic generalized epilepsy, TLE = temporal lobe epilepsy, pspin = p-value corrected against a null distribution of effects using a spatial permutation model, prand = p-value corrected against a null distribution of effects using a “random-gene” permutation model.
