Fig. 1: Cryo-EM structures of the complexes of Gs and β1-AR bound with a partial agonist or a very weak partial agonist. | Nature Communications

Fig. 1: Cryo-EM structures of the complexes of Gs and β1-AR bound with a partial agonist or a very weak partial agonist.

From: Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies

Fig. 1

a Comparison of the cellular cAMP responses induced by isoproterenol, dobutamine, and cyanopindolol. Data are presented as mean ± SD of three experiments. Source data are provided as a Source Data file. b Cartoon diagrams of the dobutamine–β1-AR–Gs complex are shown. c Cartoon diagrams of the cyanopindolol–β1-AR–Gs complex are shown. β1-AR in red, Ras-like GTPase domain of Gαs in green, Gβ in blue, Gγ in yellow, and Nb35 nanobody in orange.

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