Fig. 4: Flexibility changes of the agonist–β1-AR–Gs complexes observed in GaMD simulations. | Nature Communications

Fig. 4: Flexibility changes of the agonist–β1-AR–Gs complexes observed in GaMD simulations.

From: Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies

Fig. 4

a, d The root-mean-square fluctuations (RMSFs) of the isoproterenol–β1-AR–Gs complex. b, e Changes in RMSFs of β1-AR and Gs when the dobutamine–β1-AR–Gs complex compared with the isoproterenol–β1-AR–Gs complex. c, f Changes in RMSFs of β1-AR and Gs when the cyanopindolol–β1-AR–Gs complex compared with the isoproterenol–β1-AR–Gs complex.

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