Fig. 6: Effects of β1-AR mutations on the time-dependent cellular cAMP responses initiated by three different ligands. | Nature Communications

Fig. 6: Effects of β1-AR mutations on the time-dependent cellular cAMP responses initiated by three different ligands.

From: Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies

Fig. 6

Time-dependent cAMP responses induced by isoproterenol (a), dobutamine (b), or cyanopindolol (c), are decreased by the β1-AR mutations. Data are presented as mean ± SD of three experiments. When comparing with the wild-type receptor, all mutant receptors showed significant difference with p values <0.05 (Student’s t-test, two-sided). The color keys for the receptor mutants are displayed in (a), and are the same for (a, b, and c). Source data are provided as a Source Data file.

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