Fig. 4: Triple contact data are well described by the models, especially by the eLE and the LE+SBS. | Nature Communications

Fig. 4: Triple contact data are well described by the models, especially by the eLE and the LE+SBS.

From: Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding

Fig. 4

Triple contact probability maps are shown in microscopy data6 (left) and in the models from three different viewpoints a, b, c, more viewpoints in Supplementary Fig. 19. d The mean relative squared difference (MRSD) between imaging and model triplet contact maps is the lowest in the LE + SBS model, which is statistically equivalent to the eLE model (two-sided Welch’s t-test p = 0.097). The control is made of randomly folded self-avoiding polymer chains with same number of beads and size than the experimental structures. Error bars represent SEM. n = 1000 independent single-molecule conformations for each model. Source data are provided as a Source Data file.

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