Fig. 2: Increased expression levels of Syt13 associate with the β cell program.

a Violin plot of Syt13 expression levels in endocrine progenitors and precursors. b Dot plot of Syt13 expression in endocrine precursors at different developmental stages. c Violin plot shows the dividing of the endocrine precursors into Syt13^high and Syt13^low/− clusters. d The percentage of Syt13^high Ngn3^high and Syt13^low/− Ngn3^high cells at different developmental stages. e Heatmap of top 21 differentially expressed genes in Syt13^high and Syt13^low/− precursors. f Dot plot indicating the differential expression of EP-signature genes in Syt13^high and Syt13^low/− precursors. g Violin plots showing the expression of β cell-specific genes in Syt13^high and Syt13^low/− precursors. h Dot plot of Syt13 expression in different Fev⁺ cells from E12.5-E15.5. i The percentage of Syt13^high and Syt13^low/− cells in different Fev⁺ cell types. j Violin plots showing the expression of β and α cell-specific genes in Syt13^high and Syt13^low/− Fev⁺ cells. k The percentage of Syt13^high and Syt13^low/− cells in different hormone⁺ endocrine cell types from E12.5–E15.5. l qPCR analysis of NVF⁺ cells sorted from pancreatic epithelium from NVF;control (WT) and NVF;Syt13 KO mice at E15.5. n = 4 (control) and n = 3 (KO) independent pancreata. All statistics have been done using two-sided t-test. Data are represented as mean ± SD. Source data are provided as a Source Data file.