Fig. 4: Treatment of glyceryl triacetate (GTA) with or without alcohol artificially enriches blood acetate and mimics microbial changes observed in ethanol only treatment but does not damage the liver.
From: Acetate reprograms gut microbiota during alcohol consumption
a Whole blood Short Chain Fatty Acid (SCFA) measurements, b serum alanine transaminase (ALT), c hepatic triglyceride (TG) liver damage measurements, and d representative sections of the liver after hematoxylin and eosin staining between intragastric feeding model of continuous infusion of ethanol or glucose with or without GTA in mice (N = 4). Scale bar, 100 µM. e Beta-diversity distance from Ethanol-GTA treatment group compared between treatment groups. p value determined by pairwise PERMANOVA between treatment groups. f The log-ratio of Bacteroides and Enterococcaceae (y-axis) compared between treatments (x-axis). Box plots represent the minimum, maximum, median, first, and third quartile values (shaded region). Significance was evaluated by a two-sided Wilcoxon rank sum test with Tukey’s HSD post-hoc test adjusted p values of less than 0.05 were shown in the figure (N = 29). Source data are provided as a Source Data file.
