Fig. 3: Scope of Defluorinative Allylation.
From: Carbodefluorination of fluoroalkyl ketones via a carbene-initiated rearrangement strategy
Reaction conditions: all reactions were carried out with 1 (0.3 mmol, 1.0 equiv), 2c/2d (0.6 mmol, 2.0 equiv), K2CO3 (0.6 mmol, 2 equiv) and TpBr3Ag (10 mol%) in 1,2-dichloroethane (DCE) (4 mL) at 80 °C. Isolated yields. *1 (0.3 mmol, 1.0 equiv), 2 (0.6 mmol, 2.0 equiv), N,N-diisopropylethylamine (DIPEA) (0.6 mmol, 2 equiv) and Rh2(esp)2 (2 mol%) in DCE (4 mL) at 80 °C. Ar aryl, HetAr heteroaryl, TBDMS tert-butyldimethylsilyl, Bn benzyl, TMS trimethylsilyl, nBu n-butyl, dr diastereomeric ratio.
