Fig. 7: A model for the RalGAPα1−RalA signal module as a critical regulator of SERCA2a.
From: The RalGAPα1–RalA signal module protects cardiac function through regulating calcium homeostasis
A diagrammatic illustration represents the proposed model in which the RalGAPα1−RalA signal module regulates Ca2+ homeostasis in cardiomyocytes via interacting with SERCA2a. GDP-bound RalA interacts with SERCA2a, and enhances its function to regulate Ca2+ homeostasis. Pressure-overload upregulates RalGAPα1 in the heart and converts RalA into its GDP-bound form, which consequently plays a protective role in the heart.
