Fig. 6: Histological characterization of Clk4-cKO hearts with NEXN phosphorylation supplementation. | Nature Communications

Fig. 6: Histological characterization of Clk4-cKO hearts with NEXN phosphorylation supplementation.

From: CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation

Fig. 6

a H&E-stained heart sections from AAV-WT, AAV-S437E, and AAV-S437A hearts. Scale bar: 1 mm. b, c Summary data for LV internal diameter (LVID) and interventricular septum (IVS) thickness. d, e WGA staining, and quantification of the cardiomyocyte cross-sectional area. Scale bar: 50 μm. f, g WGA staining, and quantification of the cardiomyocyte length. Scale bar: 25 μm. h, i Masson’s trichrome staining of heart sections and quantification of myocardial fibrosis. Scale bar: 50 μm. For all panels, n = 5 animal per group. All statistical analyses were performed using one-way ANOVA and Dunnett multiple comparisons test. Data are presented as the means ± S.E.M.; P values are shown in each graph. Source data are provided as a Source Data file.

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