Fig. 6: Interaction between B. wexlerae and butyrate-producing bacteria. | Nature Communications

Fig. 6: Interaction between B. wexlerae and butyrate-producing bacteria.

From: Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Fig. 6

A Heatmap showing correlated relationship among human intestinal bacteria (n = 217). Red and blue fonts indicate bacterial genera from Fig. 1 that were positively or inversely, respectively, related to BMI/T2DM. B Positive correlation between Blautia and Butyricicoccus in human fecal samples (n = 217) (Pearson, two-tailed P value). C Estimation of Butyricicoccus species according to BlastN analysis of representative OTU sequences. D The absorbance of Butyricicoccus faecihominis-cultured medium in which the organisms were grown in the absence or presence of B. wexlerae-cultured medium at a final concentration of 1% or 10% (n = 4, mean ± 1 SD). ****P < 0.0001 (one-way ANOVA). E The absorbance of B. faecihominis-cultured medium in which the organisms were grown in the absence (none) or presence of 10 mM succinate, 10 mM lactate, or 10 mM acetate (n = 4, mean ± 1 SD). **P = 0.0019 (one-way ANOVA). F The concentration of butyrate in B. faecihominis-cultured medium in which the organisms were grown in the absence (none) or presence of B. wexlerae culture supernatant at 10%, 10 mM succinate, 10 mM lactate, or 10 mM acetate (n = 3–4, mean ± 1 SD). ***P = 0.0010; ****P < 0.0001 (one-way ANOVA). Data are representative of two independent experiments (D–F).

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