Fig. 4: Redundancy of DinB1 and DnaE2 in tolerance to alkylation damage and N2-dG adducts. | Nature Communications

Fig. 4: Redundancy of DinB1 and DnaE2 in tolerance to alkylation damage and N2-dG adducts.

From: Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis

Fig. 4

Sensitivities of indicated strains to a and b MMS, c and d MNNG, or e and f NFZ were measured by disc diffusion assay. Translesion polymerases were expressed under their native promoter from a genome integrated vector in panels b, d, and f. Results shown are means (±SEM) of data obtained from biological replicates symbolized by gray dots. Stars above the means mark a statistical difference with the reference strain (WT or ΔdnaE2dinB123 + empty in complementation experiments) (*, P < 0.05; **, P < 0.01; ***, P < 0.001). p values were obtained on log-transformed data by one-way ANOVA with a Bonferroni post-test.

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