Fig. 6: DinB1 is the primary mediator of spontaneous −1 frameshift mutations in homo-oligonucleotide runs. | Nature Communications

Fig. 6: DinB1 is the primary mediator of spontaneous −1 frameshift mutations in homo-oligonucleotide runs.

From: Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis

Fig. 6

a, b leu+ or c kanR frequency in the indicated strains and relative (pie chart) or absolute (bar chart) frequencies of nucleotide changes detected in leuD or kan coded by color. The number of sequenced leu+ or kanR colonies is given in the center of each pie chart. Results shown are means (± SEM) of data obtained from biological replicates symbolized by gray dots. Stars above bars mark a statistical difference with the reference strain (WT) and lines connecting two strains show a statistical difference between them (*, P < 0.05; **, P < 0.01; ***, P < 0.001). p-values were obtained on log-transformed data by one-way ANOVA with a Bonferroni post-test.

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