Fig. 7: DnaE2 is the primary mediator of DNA damage-induced −1 frameshift mutations in homo-oligonucleotide runs. | Nature Communications

Fig. 7: DnaE2 is the primary mediator of DNA damage-induced −1 frameshift mutations in homo-oligonucleotide runs.

From: Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis

Fig. 7

a leu+ or b kanR frequency in indicated strains/conditions and relative (pie chart) or absolute (bar chart) frequencies of nucleotide changes detected in leuD or kan coded by color. The number of sequenced leu+ or kanR colonies is given in the center of each pie chart. Results shown are means (±SEM) of data obtained from biological replicates symbolized by gray dots. Stars above bars mark a statistical difference with the reference strain (WT + UV) and lines connecting two strains show a statistical difference between them (*, P < 0.05; **, P < 0.01; ***, P < 0.001). p values were obtained on log-transformed data by one-way ANOVA with a Bonferroni post-test.

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